A multidisciplinary panel inclusive of thyroid endocrinologists, surgeons, and pathologists discuss how they have implemented the molecular markers as prognostic tools to aid clinical and surgical decision making.
Dr. Erik K. Alexander is Chief of the Thyroid Section at the Brigham & Women's Hospital, and Professor of Medicine at Harvard Medical School. He is an expert in the field of thyroid nodule evaluation and thyroid cancer care, having published over 200 peer reviewed articles including seminal works in the NEJM, Lancet Endocrinology, JAMA, and the Annals of Internal Medicine. Erik is a member of the 2015 ATA Thyroid Nodule and Cancer clinical guidelines committee, and separately co-chaired the 2017 ATA clinical guidelines on Thyroid illness during Pregnancy. Dr Alexander is a former member of the ATA's Board of Directors. His current work focuses upon novel molecular and genomic understand of disease, and the ability of such efforts to influence prognostic strategy for patients ahead. Separate from his thyroid expertise, Erik is a passionate medical educator and serves as BWH Vice President of Education and HMS Associate Dean for Medical Education.
Dr. Sadow, Director of Head and Neck Pathology, is also a subspecialist in Genitourinary Pathology and a consultant in Endocrine Pathology, a subspecialty with many homes by organ system. He returned to MGH almost two decades after getting his first taste of research at MGH as a summer student while an undergraduate at Johns Hopkins University. Dr. Sadow's first project (and publication) involved the effects of thyroid hormone on tissue remodeling and wound repair. It was a desire to advance our knowledge of human disease that drove Dr. Sadow to pursue a combined MD/PhD program at the University of Chicago rather than pursuing his other academic passion of Egyptian art and archaeology, having studied Egyptology along with biology as an undergraduate. He has maintained his archaeological interests, even as a pathologist at MGH, and he was in Egypt with a Johns Hopkins excavation team during the Arab Spring in January of 2011. Dr. Sadow's doctoral thesis at the University of Chicago utilized transgenic mouse models with altered thyroid hormone response genes in order to understand and advance our knowledge of the effects of thyroid hormone on human physiology. This desire to understand the pathophysiology of endocrine dysfunction led Dr. Sadow to pursue clinical training in Anatomic Pathology at Brigham and Women's Hospital, where he was born, followed by subspecialty training in Endocrine, Genitourinary, and Head & Neck Pathology. His clinical and research interests have continued in endocrine pathology, studying the mechanisms of endocrine carcinogenesis through translational studies involving the proteomics and genomics of endocrine neoplasia, primarily of the thyroid & adrenal glands. In addition to his clinical & research interests, Dr. Sadow has prominent teaching roles in the hospital, medical school, and in continuing medical education courses.
Dr. Nancy Cho received her A.B. from Harvard College, magna cum laude in Biochemical Sciences, and M.D. from Columbia University, College of Physicians and Surgeons. She completed her General Surgery training at Brigham and Women’s Hospital (BWH) where she spent two years as a Clinical Research Fellow in Surgical Oncology studying the molecular biology of carcinogenesis. Following residency, she completed a fellowship in Endocrine Surgery at BWH and was recruited to join the faculty. She is currently an Associate Surgeon at BWH and Dana Farber Cancer Institute and Assistant Professor of Surgery at Harvard Medical School. Her clinical practice focuses on endocrine diseases of the thyroid/parathyroid glands as well as melanoma surgery. Her primary research focus involves clinical outcomes in surgical oncology and gender disparity in academic medicine. She is the Associate Clerkship Director for Harvard Medical School and works closely with residents, medical students, and fellows to optimize delivery of patient care and improve surgical outcomes. Dr. Cho is the recipient of a number of career development awards and has authored over 50 peer-reviewed publications.
Trevor E Angell, MD is Assistant Professor of Clinical Medicine and Associate Director of the Thyroid Center in the Division of Endocrinology and Diabetes at Keck School of Medicine of the University of Southern California. He received his MD and completed internal medicine residency and endocrinology fellowship at the Keck School of Medicine and LAC+USC Medical Center. He joined the Endocrinology faculty of Brigham and Women’s Hospital and Harvard Medical School conducting clinical research in thyroid nodules before returning to USC. His clinical and research interests include all thyroid disease, with focus on the diagnosis and management of nodules and cancer. He is Co-Director of the USC Peter A Singer Thyroid Symposium, serves on the editorial boards of Thyroid, Clinical Thyroidology, and Frontiers in Endocrinology, and is Past-Chair of the American Thyroid Association Patient Affairs and Education Committee.